Potassium Iodide → HCID 68638032, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide hydrochloride (0.25 g, 0.49 mmol), potassium phthalimide (0.109 g, 0.59 mmol), potassium carbonate (0.081 g, 0.59 mmol) and potassium iodide (0.098 g, 0.59 mmol) in dimethylacetamide (2 ml) was heated at 75° C. for 16 hours. The reaction mixture was allowed to cool to room temperature. Aqueous sodium hydrogen carbonate was added to the mixture and the resultant precipitate was filtered and washed with water, acetonitrile then diethyl ether to give N-(2,3-difluorophenyl)-2-[4-({7-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]quinazolin-4-yl}amino)-1H-pyrazol-1-yl]acetamide (0.214 g, 75% yield):

Provenance & Evidence