HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 640004Generated: October 29, 2026
Dimethylformamide → 7-(Benzyloxy)-4-chloroquinazoline
https://huagongshe.com/reaction/640004
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-(Benzyloxy)-3,4-dihydroquinazolin-4-one | HCID 135763110 | — |
| Product | 7-(Benzyloxy)-4-chloroquinazoline | HCID 22030923 | 90% |
Reaction Steps
A solution of 7-(benzyloxy)quinazolin-4(3H)-one (5.0 g, 19.8 mmol) in thionyl chloride (40 ml) containing a catalytic amount of dimethylformamide was heated at 90° C. for 2 hours. The solvent was concentrated in vacuo and the oily residue co-evaporated with toluene (2×100 ml) to leave a yellow solid which was triturated with diethyl ether to yield 7-(benzyloxy)4-chloroquinazoline (4.79 g, 90% yield) as a pale yellow solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07691867B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-de0a66b5d15546f1b4fa21bd5e347510 |
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| Source note | uspto-grants-2010_04 |
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