HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 640083Generated: October 30, 2026
Acetic Acid → (E)-2-((4-(2-Nitrovinyl)benzyl)oxy)pyridine
https://huagongshe.com/reaction/640083
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 4-((Pyridin-2-yloxy)methyl)benzaldehyde | HCID 59255118 | — |
| Solvent | Water | HCID 962 | — |
| Product | (E)-2-((4-(2-Nitrovinyl)benzyl)oxy)pyridine | HCID 58076258 | 74.5% |
Reaction Steps
A mixture of 4-(pyridin-2-yloxymethyl)-benzaldehyde (23.4 g, 110 mmol) described in Manufacturing Example 2-1-2, nitromethane (33.6 g, 550 mmol), ammonium acetate (17.0 g, 220 mmol) and acetic acid (200 mL) was stirred for 1 hour and 45 minutes at 100° C. The reaction solution was stirred on an ice bath while adding a small amount of water, and the precipitated solids were filtered to obtain the title compound (21.0 g, 74.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07691882B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-d59211ca82314495befbc94ff502fd36 |
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| Source note | uspto-grants-2010_04 |
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