反应详情

Acetic anhydride (0.7 ml, 8.433 mmol) was added dropwise at 0° C. to 1H-pyrazol-4-amine (0.7 g, 8.433 mmol). The mixture was stirred for 30 min at RT and quenched by the addition of crushed ice. The mixture was extracted with ethyl acetate The combined organic layer was washed with water, brine and dried over sodium sulphate. The solvent was distilled off to afford the product in 54% yield. (0.6 g). LC-MS (ESI): Calculated mass: 125.0; Observed mass 126.0 [M+H]+ (rt: 0.115 min).

1. customquenched by the addition of crushed ice
2. extractionThe mixture was extracted with ethyl acetate The combined organic layer
3. washwas washed with water, brine
4. dry with materialdried over sodium sulphate
5. distillationThe solvent was distilled off
6. customto afford the product in 54% yield
7. customObserved mass 126.0 [M+H]+ (rt: 0.115 min)