HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → (4aR,7aR)-Octahydro-1H-pyrrolo(3,4-b)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | (R,R)-6-(toluene-4-sulfonyl)-octahydro-pyrrolo[3,4-b]pyridine | HCID 44227364 | — |
| Product | (4aR,7aR)-Octahydro-1H-pyrrolo(3,4-b)pyridine | HCID 1515156 | 84.4% |
Reaction Steps
The title compound (9.12 g) is prepared from mixture system of (R,R)-6-(toluene-4-sulfonyl)-octahydro-pyrrolo[3,4-b]pyridine (24.0 g), hydrobromic acid (48%, 156 ml), propionic acid (72 ml) and phenol (14.6 g) following the same procedure described in example 9. After conventional work up and distillation 3.4 g of oil is obtained (yield: 78.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07692015B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-88b39cc0ec8649c9be66aa8c615bfd7f |
| Source note | uspto-grants-2010_04 |