反应详情

A solution of trityl candesartan cilexetil (TCS, 350 g, 410.3 mmol), toluene (1050 ml), methanol (2100 ml), and water (17.5 ml) was refluxed for about 3 h (HPLC control). The solvents were evaporated at 45° C. at 90 mbar to give a residue as a viscous oil, the residue was dissolved at 50° C. in a mixture of toluene/methanol (1041 g, 95:5 w/w) to give 1391 g of a clear solution.

1. customThe solvents were evaporated at 45° C. at 90 mbar