HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Candesartan Cilexetil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Trityl candesartan cilexetil | HCID 11029254 | — |
| Solvent | Water | HCID 962 | — |
| Product | Candesartan Cilexetil | HCID 2540 | — |
Reaction Steps
A solution of trityl candesartan cilexetil (TCC, 30.0 g, 35.17 mmol), toluene (180 mL), methanol (180 mL), and water (1.6 mL) was refluxed for about 13 h (HPLC control), and the solvents were evaporated at 60° C./30 mbar to give a residue as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07692023B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-a0669659e51b498c8ed182bccc7d11ee |
| Source note | uspto-grants-2010_04 |