2-Bromopropane → 4-Bromo-1-isopropyl-1H-pyrazole

Participants

Reaction Steps

To a solution of 4-bromo-1H-pyrazole (5 g, 34.24 mmol, 1.0 eq) in DMF were added K2CO3 (11.83 g, 85.60 mmol, 2.5 eq.) and 2-bromopropane (6.31 g, 51.36 mmol, 1.5 eq.) The mixture was stirred at RT for 12 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 76.9% yield (5.0 g).

Provenance & Evidence