HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 8-Isopropoxy-2-methyl-4-phenyl-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 4-Chloro-8-isopropoxy-2-methyl-quinazoline | HCID 59256694 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 8-Isopropoxy-2-methyl-4-phenyl-quinazoline | HCID 59256649 | — |
Reaction Steps
To a stirred mixture of 4-chloro-8-isopropoxy-2-methyl-quinazoline (35) (0.58 mmol), phenylboronic acid (0.62 mmol), 2 N Na2CO3 (7.2 mL), EtOH (1.2 mL) and benzene (6 mL) was added, under a blanket of argon, Pd(PPh3)4 (20 mg). The mixture was stirred under reflux for 16 h, cooled, and concentrated. Subsequent column chromatography (ethyl acetate/hexane) provided 8-isopropoxy-2-methyl-4-phenyl-quinazoline (36) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07692011B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-98787b82a8bb43a79cf632c7b07856d8 |
| Source note | uspto-grants-2010_04 |