Methyl iodide → HCID 594849, compound

Participants

Reaction Steps

According to the procedure previously described in Example 6, 8-hydroxy-quinazoline (A1) (20 mmol) and iodomethane gave 8-methoxy-quinazoline (111). 8-Methoxy-quinazoline (111) (10 mmol) was then treated with m-chloroperbenzoic acid which gave the N-oxide 112. Subsequent treatment of the N-oxide 112 with Ac2O and phosphorus oxychloride according to Example 14 afforded 2-chloro-8-methoxy-quinazoline (113).

Provenance & Evidence