HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 2-Pyrazol-1-yl-quinazolin-8-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 2-Chloro-8-methoxyquinazoline | HCID 19988695 | — |
| Product | 2-Pyrazol-1-yl-quinazolin-8-ol | HCID 68562268 | — |
Reaction Steps
A mixture of the 2-chloride 113 (0.5 mmol) and pyrazole (2.5 mmol) was heated at 175° C. in a steel autoclave for 48 h. The crude product was then treated with BBr3 according to the procedure described in Example 6. Subsequent purification by column chromatography gave 2-pyrazol-1-yl-quinazolin-8-ol (A131).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07692011B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-79edada64f544434924c09e095eecdcc |
| Source note | uspto-grants-2010_04 |