N-bromobutanimide → HCID 59256701, compound

HRID 640792Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][N:8]=[CH:7]2.C1C(=O)N([Br:19])C(=O)C1>>[Br:19][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[C:11]2[C:6]=1[CH:7]=[N:8][CH:9]=[N:10]2

Participants

Reactant 2

HCID 67184N-bromobutanimide

HCID 5896918-Quinazolinol

Product 1

HCID 59256701HCID 59256701, compound

Procedure

Bromination of 8-hydroxy-quinazoline (A1) with N-bromosuccimide, according to the method previously described by Gerson and McNeil,15 gave 5-bromo-8-hydroxy-quinazoline (A139).

Sources & evidence

ORD record: ord-ddbbda4bf43c43828d1ffb2af0e86405
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07692011B2

Reaction notes

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