反应详情

Acetic anhydride (14 ml) was added dropwise at 0° C. to 3-bromo-5-nitroaniline (14 g, 64.5 mmol). The mixture was stirred for 30 min at RT and then quenched by the addition of crushed ice. The precipitate formed was filtered and washed with cold water to obtain off-white solid. The solid was dried under vacuum to give the product in 78% yield (13 g). 1H NMR (300 MHz, DMSO-d6): δ 10.54 (br s, 1H), 8.45 (s, 1H), 8.2 (s, 1H), 8.03 (s, 1H), 2.11 (s, 3H).

1. customquenched by the addition of crushed ice
2. customThe precipitate formed
3. filtrationwas filtered
4. washwashed with cold water
5. customto obtain off-white solid
6. customThe solid was dried under vacuum
7. customto give the product in 78% yield (13 g)