HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 117777633, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)acetamide | HCID 71554408 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 117777633 | HCID 117777633 | 58% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of the compound of Example 8 (1.5 g, 3.0 mmol) in ethanol (30 ml) was added aqueous solution of NaOH (1.5 g, 37.5 mmol, 12.5 eq.) and the mixture was heated at 100° C. for 4 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 58% yield (0.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447091B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b3ccccb1a5174b308b2e524f471fb132 |
| Source note | uspto-grants-2016_09 |