Sodium Hydroxide → 2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

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Reaction Conditions

Reaction Steps

To a solution of the compound of Example 17 (300 mg, 0.675 mmol) in ethanol (10 ml) was added aqueous solution of NaOH (338 mg, 8.44 mmol, 12.5 eq.) and the mixture was heated at 85° C. for 5 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 44% yield (0.12 g). LC-MS (ESI): Calculated mass: 402.4; Observed mass: 403.4 [M+H]+ (rt: 1.03 min).

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