反应详情

温度

85 °C

To a solution of the compound of Example 53 (0.6 g, 1.41 mmol) in ethanol (20 ml) was added aqueous solution of NaOH (451 mg, 11.3 mmol, 8.0 eq.) and the mixture was heated at 85° C. for 4 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 44% yield (0.24 g). LC-MS (ESI): Calculated mass: 383.42; Observed mass: 384.1 [M+H]+ (rt: 1.004 min).

1. customThe mixture was quenched
2. extractionextracted as in Example 1(d)
3. distillationThe solvent was distilled off
4. customto afford the product in 44% yield (0.24 g)
5. custom384.1 [M+H]+ (rt: 1.004 min)