反应详情

温度

85 °C

To a solution of the compound of Example 70 (0.6 g, 1.46 mmol) in ethanol (40 ml) was added aqueous solution of NaOH (1.0 g, 25 mmol, 17.1 eq.) and the mixture was heated at 85° C. for 5 h. The mixture was quenched and extracted as in Example 1(d). The combined organic layer was washed with water, brine and dried over sodium sulphate. The solvent was distilled off to afford the product in 84% yield (0.45 g).

1. customThe mixture was quenched
2. extractionextracted as in Example 1(d)
3. washThe combined organic layer was washed with water, brine
4. dry with materialdried over sodium sulphate
5. distillationThe solvent was distilled off
6. customto afford the product in 84% yield (0.45 g)