Cyclopropanesulfonyl chloride → HCID 117777821, compound

HRID 64105Notes

Reaction equation

[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:31]=[CH:30][C:10]3[N:11]([C:14]4[CH:15]=[C:16]([NH:26]C(=O)C)[CH:17]=[C:18]([C:20]5[O:21][C:22]([CH3:25])=[CH:23][CH:24]=5)[CH:19]=4)[CH:12]=[N:13][C:9]=3[CH:8]=2)[CH:4]=[N:3]1.[CH:32]1([S:35](Cl)(=[O:37])=[O:36])[CH2:34][CH2:33]1>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:31]=[CH:30][C:10]3[N:11]([C:14]4[CH:15]=[C:16]([NH:26][S:35]([CH:32]5[CH2:34][CH2:33]5)(=[O:37])=[O:36])[CH:17]=[C:18]([C:20]5[O:21][C:22]([CH3:25])=[CH:23][CH:24]=5)[CH:19]=4)[CH:12]=[N:13][C:9]=3[CH:8]=2)[CH:4]=[N:3]1

Participants

Reactant 2

HCID 2760919Cyclopropanesulfonyl chloride

HCID 89501159HCID 89501159, compound

Product 1

HCID 117777821HCID 117777821, compound

Procedure

The compound was prepared from the compound of Example 73 using the procedures of Example 74 and cyclopropane sulfonyl chloride. 1H NMR (300 MHz, CD3OD): δ 8.5 (s, 1H), 8.0 (s, 1H), 7.95 (s, 1H), 7.9 (s, 1H), 7.6-7.7 (m, 4H), 7.5 (s, 1H), 6.8 (d, 1H), 6.2 (s, 1H), 4.0 (s, 3H), 2.4 (s, 3H), 1.0-1.5 (m, 4H). LC-MS (ESI): Calculated mass: 473.55; Observed mass: 474.0 [M+H]+ (rt: 1.382 min).

Workup

custom474.0 [M+H]+ (rt: 1.382 min)

Sources & evidence

ORD record: ord-4b7d2b32af364172908e28107e59c303
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447091B2

Reaction notes

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