反应详情

To a suspension of Nitrobenzene (NB-2-A13, NB-2-A14 or NB-3-A16; 1.61 mmol) and Raney Ni (50 mg) in refluxing ethanol (10 mL) was added drop-wise anhydrous hydrazine (0.5 mL). After the addition was complete, the mixture was refluxed for an additional 20 minutes and then filtered through a pad of Celite. The Celite bed was washed with ethanol (100 mL) and the combined solution was evaporated under reduced pressure to provide pure 2-(4-aminophenyl)-acetamide (2-NB-2-A13, 2-NB-2-A14 or 2-NB-3-A16).

1. additionAfter the addition
2. temperaturethe mixture was refluxed for an additional 20 minutes
3. filtrationfiltered through a pad of Celite
4. washThe Celite bed was washed with ethanol (100 mL)
5. customthe combined solution was evaporated under reduced pressure