Dimethylformamide → HCID 86612168, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2-Benzimidazolecarboxylic acid	HCID 233240	—
Reactant	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Solvent	Water	HCID 962	—
Product	HCID 86612168	HCID 86612168	—

Reaction Steps

0.064 mmol of benzimidazolecarboxylic acid 4f was dissolved in DMF together with 0.064 mmol of the amine 5c, a solution of TBTU (0.096 mmol) in DMF, HOBT (0.026 mmol) in DMF and 0.32 mmol of DIPEA were added successively, and the mixture was stirred at room temperature. After 3 hours, a further 0.3 eq. of acid was added, and the mixture was stirred overnight. The reaction mixture was diluted with water, and the resulting precipitate was filtered off with suction and washed with water.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07691870B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-7c9629a80f974dab924227aafcae8d7a
Source note	uspto-grants-2010_04