Water → HCID 86612170, compound

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2-Benzimidazolecarboxylic acid	HCID 233240	—
Reactant	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 86612170	HCID 86612170	—

Reaction Steps

0.064 mmol of benzimidazolecarboxylic acid 4f was dissolved in DMF together with 0.064 mmol of the amine 5d, a solution of TBTU (0.096 mmol) in DMF, HOBT (0.026 mmol) in DMF and 0.32 mmol of DIPEA were added successively, and the mixture was stirred at room temperature. After 3 hours, a further 0.3 eq. of acid was added, and the mixture was stirred for 2 hours. The reaction mixture was diluted with water, and the resulting precipitate was filtered off with suction and washed with water.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07691870B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-877e3261cca549c5912b08146c9009c7
Source note	uspto-grants-2010_04