反应详情

Acetic anhydride (7.0 ml) was added to 3-nitro-5-pyrrol-1-yl-phenylamine (7.0 g, 34.48 mmol). The mixture was stirred for 30 min at RT and subsequently quenched by the addition of crushed ice. The precipitate formed was filtered and was washed with cold water to obtain off-white solid. The solid was dried under high vacuum to give the product in 89% yield (7.52 g). LC-MS (ESI): Calculated mass: 245.23; Observed mass: 244.1 [M−H]+ (rt: 0.24 min).

1. customsubsequently quenched by the addition of crushed ice
2. customThe precipitate formed
3. filtrationwas filtered
4. washwas washed with cold water
5. customto obtain off-white solid
6. customThe solid was dried under high vacuum
7. customto give the product in 89% yield (7.52 g)
8. custom244.1 [M−H]+ (rt: 0.24 min)