Diisopropylamine → HCID 178456730, compound

Participants

Reaction Steps

In a stainless steel autoclave, 700 mg (2.0 mmol) of 3-(2-chloro-6-fluorophenyl)-2,4-dichloro-6-([1,2,4]triazolyl)pyridine (Example A) and 15 g of diisopropylamine were heated at 160° C. for 12 h. The volatile components were removed under reduced pressure and the residue was chromatographed on silica gel using cyclohexane/ethyl acetate. It was possible to isolate 240 mg of 2-chloro-3-(2-chloro-6-fluorophenyl)-4-(2-propylamino)-6-([1,2,4]triazolyl)pyridine (m.p. 152° C.) and 310 mg of 4-chloro-3-(2-chloro-6-fluorophenyl)-2-(2-propylamino)-6-([1,2,4]triazolyl)pyridine (m.p. 152° C.).

Provenance & Evidence