4-Methylpiperidine → HCID 24853493, compound

Participants

Reaction Steps

In a stainless steel autoclave, 500 mg (1.4 mmol) of 3-(2-chloro-6-fluorophenyl)-2,4-dichloro-6-(pyrimidin-2-yl)pyridine (Example C) and 15 g of 4-methylpiperidin were heated at 140° C. for 12 h. The volatile components were removed under reduced pressure and the residue was chromatographed on silica gel using cyclohexane/ethyl acetate. It was possible to isolate 220 mg of 4-chloro-3-(2-chloro-6-fluorophenyl)-2-(4-methylpiperidinyl)-6-(pyrimidin-2-yl)pyridine (m.p. 129° C.) and 60 mg of 2-chloro-3-(2-chloro-6-fluorophenyl)-4-(4-methylpiperidinyl)-6-(pyrimidin-2-yl)pyridine (m.p. 129° C.).

Provenance & Evidence