Hydrochloric Acid → HCID 11419691, compound

Participants

Reaction Steps

A solution of {(R)-1-Hydroxymethyl-3-[3-methoxy-4-(4,4,5,5,5-pentafluoro-pentyloxy)-phenyl]-1-methyl-propyl}-carbamic acid tert-butyl ester (32 mg, 0.07 mmol) in acetic acid (1 ml), conc. HCl (0.027 ml) and H2O2 (30%, 0.074 ml) is stirred at RT for 2 h. After evaporation of the solvent at RT, the oily residue is treated with toluene (1 ml), which is distilled off at RT. Et2O is added and the white precipitate is filtered off to yield the title compound. MS (ESI+): m/z=420/422 (MH+).

Provenance & Evidence