HCID 178521641, compound → HCID 66696651, compound

Participants

Reaction Steps

A solution of (4S,2R,3R,5R)-2-(benzoxazol-2-ylaminomethyl)-5-[6-(tetrahydrofuran-3-yl)-purin-9-yl]-tetrahydrofuran-3,4-diol acetonide, a compound of formula (12), in 80% acetic acid in water (10 mL) was heated to 80° C. for 16 hours. Solvent was evaporated form the reaction product and the residue was purified by preparative TLC (5% MeOH/DCM) to give (4S,2R,3R,5R)-2-(benzoxazol-2-ylaminomethyl)-5-[6-(tetrahydrofuran-3-yl)-purin-9-yl]-tetrahydrofuran-3,4-diol as a white foam. MS (M+1).

Provenance & Evidence