反应详情

1-(6-chloro-2-morpholin-4-yl-pyrimidin-4-yloxy)-2-methyl-propan-2-ol (2.58 g) was dissolved in dioxane (50 mL) and hydrazine (3 mL) was added. The solution was heated to reflux for one hour, at which point the solvent was evaporated. The solid was dissolved in dichloromethane (200 mL) and washed with 10% sodium carbonate (10 mL). The organic layer was dried over magnesium sulfate and evaporated to give 1-(6-hydrazino-2-morpholin-4-yl-pyrimidin-4-yloxy)-2-methyl-propan-2-ol, which was used without purification in the next reaction.

1. temperatureThe solution was heated
2. temperatureto reflux for one hour, at which point the solvent
3. customwas evaporated
4. dissolutionThe solid was dissolved in dichloromethane (200 mL)
5. washwashed with 10% sodium carbonate (10 mL)
6. dry with materialThe organic layer was dried over magnesium sulfate
7. customevaporated