Sodium Hydroxide → 4-(4-(1-(3-amino-5-(1H-pyrrol-1-yl)phenyl)-1H-benzo[d]imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-2-methylbutan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	N-(3-(5-(1-(3-hydroxy-3-methylbutyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)acetamide	HCID 89501342	—
Solvent	Ethanol	HCID 702	—
Product	4-(4-(1-(3-amino-5-(1H-pyrrol-1-yl)phenyl)-1H-benzo[d]imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-2-methylbutan-2-ol	HCID 117777525	58%

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a solution of the compound of Example 112 (150 mg, 0.32 mmol) in ethanol (10 ml) was added aqueous solution of NaOH (160 mg, 4 mmol, 12.5 eq.) and the mixture was heated at 80° C. for 2 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 58% yield (80 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09447091B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-8be034cc45d547fd93b91d799ecf7013
Source note	uspto-grants-2016_09