HCID 49857273, compound → HCID 49857274, compound

Participants

Reaction Steps

In a round bottom flask, 2-morpholin-4-yl-8-(1-nitro-dibenzothiophen-4-yl)-1H-quinolin-4-one (24)(365 mg; 0.798 mmol) was suspended in AcOH (5 mL). Zinc powder (5223.3 mg; 7.98 mmol) was added to this solution and the reaction was stirred at room temperature overnight. The reaction mixture was filtered through Celite™, washed successively with methanol (4×25 mL) and DCM (4×25 mL). The combined organic layers were evaporated under reduced pressure. The residue was stirred with water (50 mL) and aqueous ammonia (15 mL) was added to the solution. The resultant precipitate was collected by filtration. The residue was dried and did not require further purification. The product was obtained as a yellow solid (291.3 mg). Yield=85.4%. Mass Spec.: (m/z) 428.4 [M+1]+ (Rt=3.83 min).

Provenance & Evidence