Chlorosulfonic acid → HCID 135856749, compound

HRID 641209Notes

Reaction equation

HRID 641209 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH2:23][CH3:24])[N:18]=[C:19]([CH2:20][CH2:21][CH3:22])[N:12]2[N:11]=1)[CH3:2].[Cl:25][S:26](O)(=[O:28])=[O:27]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:26]([Cl:25])(=[O:28])=[O:27])=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH2:23][CH3:24])[N:18]=[C:19]([CH2:20][CH2:21][CH3:22])[N:12]2[N:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 1358567572-(2-Ethoxyphenyl)-5-ethyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one

Product 1

HCID 135856749HCID 135856749, compound

Procedure

At 0° C., 1.70 g (5.21 mmol) of 2-(2-ethoxy-phenyl)-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are added slowly to 3.12 ml of chlorosulphonic acid. The reaction mixture is stirred at room temperature overnight and then poured into ice-water and extracted with dichloromethane. This gives 2.10 g (94%) of a colourless foam.

Workup

  1. extractionextracted with dichloromethane

Sources & evidence

ORD record
ord-827dece09d3440978b535eb83654ade1
Source dataset
uspto-grants-2010_04
Patent number
US07696206B2

Reaction notes

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