Sodium Hydroxide → HCID 117777597, compound

HRID 64121Notes

Reaction equation

HRID 64121 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:30]=[CH:29][C:10]3[N:11]([C:14]4[CH:15]=[C:16]([NH:25]C(=O)C)[CH:17]=[C:18]([N:20]5[CH:24]=[CH:23][CH:22]=[N:21]5)[CH:19]=4)[CH:12]=[N:13][C:9]=3[CH:8]=2)[CH:4]=[N:3]1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:30]=[CH:29][C:10]3[N:11]([C:14]4[CH:15]=[C:16]([CH:17]=[C:18]([N:20]5[CH:24]=[CH:23][CH:22]=[N:21]5)[CH:19]=4)[NH2:25])[CH:12]=[N:13][C:9]=3[CH:8]=2)[CH:4]=[N:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 117777767HCID 117777767, compound

Product 1

HCID 117777597HCID 117777597, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of the compound of Example 114 (4.0 g, 10.06 mmol) in ethanol (25 ml) was added 20% aqueous solution of NaOH (5 ml) and the reaction was heated at 100° C. for 2 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 78% yield (2.8 g).

Workup

  1. customThe mixture was quenched
  2. extractionextracted as in Example 1(d)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 78% yield (2.8 g)

Sources & evidence

ORD record
ord-1b32ef1132664a1a8d075597e9be9adc
Source dataset
uspto-grants-2016_09
Patent number
US09447091B2

Reaction notes

Loading…