4-Piperidinemethanol → 2-[2-Ethoxy-5-(4-hydroxymethylpiperidine-1-sulphonyl)-phenyl]-5,7-dimethyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

HRID 641213Notes

Reaction equation

HRID 641213 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.[CH2:9]([O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](N2CCC(O)CC2C)(=[O:20])=[O:19])=[CH:14][C:13]=1[C:29]1[NH:34][C:33](=[O:35])[C:32]2=[C:36]([CH3:40])[N:37]=[C:38]([CH3:39])[N:31]2[N:30]=1)[CH3:10]>>[CH2:9]([O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([N:6]2[CH2:7][CH2:8][CH:3]([CH2:2][OH:1])[CH2:4][CH2:5]2)(=[O:19])=[O:20])=[CH:14][C:13]=1[C:29]1[NH:34][C:33](=[O:35])[C:32]2=[C:36]([CH3:40])[N:37]=[C:38]([CH3:39])[N:31]2[N:30]=1)[CH3:10]

Participants

3

Reactant 2

HCID 4207714-PiperidinemethanolHCID 1363763952-[2-ethoxy-5-(4-hydroxy-methylpiperidine-1-sulphonyl)-phenyl]-5,7-dimethyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Product 1

HCID 1355155872-[2-Ethoxy-5-(4-hydroxymethylpiperidine-1-sulphonyl)-phenyl]-5,7-dimethyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Procedure

By the same method, starting with 100 mg (0.261 mmol) of 4-ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-][1,2,4]triazin-2-yl)-benzenesulphonyl chloride and 90 mg (0.784 mmol) of 4-hydroxymethylpiperidine, 22 mg (18% of theory) of 2-[2-ethoxy-5-(4-hydroxy-methylpiperidine-1-sulphonyl)-phenyl]-5,7-dimethyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-a803cdab8604421b95cf9951eae51056
Source dataset
uspto-grants-2010_04
Patent number
US07696206B2

Reaction notes

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