3,5-Dimethylbenzenesulfonyl chloride → 4-{[4-(3,5-dimethyl-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl]-amino}-benzoic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	3,5-Dimethylbenzenesulfonyl chloride	HCID 2736235	—
Reactant	4-{[4-(3,5-Dimethyl-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl]-amino}-benzoic acid	HCID 24762629	—
Product	4-{[4-(3,5-dimethyl-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl]-amino}-benzoic acid ethyl ester	HCID 66789417	—

Reaction Steps

4-{[4-(3,5-Dimethyl-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl]-amino}-benzoic acid, MS (ISP): m/e=466.5 (M−H), was prepared as described for example 14, steps 1 to 8. Step 7 was performed using 3,5-dimethyl-benzenesulfonyl chloride and yielded 4-{[4-(3,5-dimethyl-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl]-amino}-benzoic acid ethyl ester, which was hydrolyzed in step 8.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07696200B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-31bffc679d9b434884d310cdda2c1657
Source note	uspto-grants-2010_04