Benzocaine → HCID 66789156, compound

HRID 641319Notes

Reaction equation

[Cl:1][C:2]1[C:10]2[O:9][CH2:8][N:7]([S:11]([C:14]3[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=3[O:21][CH3:22])(=[O:13])=[O:12])[C:6]=2[CH:5]=[C:4]([C:23]([OH:25])=O)[CH:3]=1.[NH2:26][C:27]1[CH:37]=[CH:36][C:30]([C:31]([O:33][CH2:34][CH3:35])=[O:32])=[CH:29][CH:28]=1>>[CH2:34]([O:33][C:31](=[O:32])[C:30]1[CH:36]=[CH:37][C:27]([NH:26][C:23]([C:4]2[CH:3]=[C:2]([Cl:1])[C:10]3[O:9][CH2:8][N:7]([S:11]([C:14]4[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=4[O:21][CH3:22])(=[O:13])=[O:12])[C:6]=3[CH:5]=2)=[O:25])=[CH:28][CH:29]=1)[CH3:35]

Participants

Reactant 2

HCID 2337Benzocaine

HCID 66789826HCID 66789826, compound

Product 1

HCID 66789156HCID 66789156, compound

Procedure

Reaction of 7-chloro-3-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-benzooxazole-5-carboxylic acid with ethyl 4-aminobenzoate in analogy with example 30, step 4 gave 4-{[7-chloro-3-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-benzooxazole-5-carbonyl]-amino}-benzoic acid ethyl ester. Light yellow solid, MS (ISP)=551.1 (M+H)+.

Sources & evidence

ORD record: ord-135dadf8d51a40639fb24075bc5e320c
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696200B2

Reaction notes

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