Water → HCID 24762482, compound

HRID 641346Notes

Reaction equation

HRID 641346 reaction equation
C([O:5][C:6](=[O:37])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]2[CH:17]=[CH:18][C:19]3[S:24](=[O:25])[CH2:23][CH2:22][N:21]([S:26]([C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[CH:30]=4)(=[O:28])=[O:27])[C:20]=3[CH:36]=2)=[O:15])=[CH:9][CH:8]=1)(C)(C)C.O>C(O)=O>[Cl:35][C:31]1[CH:30]=[C:29]([S:26]([N:21]2[C:20]3[CH:36]=[C:16]([C:14]([NH:13][C:10]4[CH:11]=[CH:12][C:7]([C:6]([OH:37])=[O:5])=[CH:8][CH:9]=4)=[O:15])[CH:17]=[CH:18][C:19]=3[S:24](=[O:25])[CH2:23][CH2:22]2)(=[O:27])=[O:28])[CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 962WaterHCID 66788875HCID 66788875, compound

Product 1

HCID 24762482HCID 24762482, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A suspension of 4-{[4-(3-chloro-benzenesulfonyl)-1-oxo-1,2,3,4-tetrahydro-benzo[1,4]thiazine-6-carbonyl]-amino}-benzoic acid tert-butyl ester (153 mg, 0.273 mmol) in formic acid (4 mL) was stirred for 16 h at room temperature, then the solution obtained was treated with water, and the suspension was stirred for another 90 min. The precipitate was collected by filtration and dried to produce the title compound (126 mg, 92%). White solid, 505.2 (M+H)+.

Workup

  1. customthe solution obtained
  2. stirringthe suspension was stirred for another 90 min
  3. filtrationThe precipitate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-378336c3d4d148ac94aaa160e490e718
Source dataset
uspto-grants-2010_04
Patent number
US07696200B2

Reaction notes

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