HCID 66636876, compound → HCID 86629736, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of dimethyl 2,2′-(5-chloro-4-nitro-2-oxo-1H-benzimidazole-1,3-diyl)diacetate (100 mg, 0.28 mmol) from Step D in AcOH (1.0 mL) and water (0.1 mL) was added fine granular iron (78 mg, 1.4 mmol) and the slurry was heated at 70° C. for 1 h. The reaction was cooled, filtered, concentrated and dissolved in DMF (4 mL). The DMF solution was added dropwise to H2O (30 mL) with stirring and the precipitate was isolated by filtration to give the title compound. MS: 777/z=296 (M+1).

Provenance & Evidence