2,6-Dichloro-3-nitropyridin-4-amine → 2,6-Dichloropyridine-3,4-diamine

Participants

Reaction Steps

To a solution of 2,6-dichloro-3-nitro-pyridin-4-amine (2.6 g, 14.4 mmol) from Step A in MeOH (150 mL) was added Raney Nickel catalyst (2 g) and the reaction agitated under a hydrogen atmosphere in a Parr apparatus (35 p.s.i.) for 2 h. The reaction mixture was filtered through a pad of Celite and concentrated to yield the title compound. MS: m/z=178 (M+1).

Provenance & Evidence