Cyclopropanesulfonyl chloride → HCID 117777526, compound

HRID 64144Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([N:15]2[C:19]3[CH:20]=[CH:21][C:22]([C:24]4[N:25]=[N:26][N:27]([CH:29]5[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]5)[CH:28]=4)=[CH:23][C:18]=3[N:17]=[CH:16]2)[CH:12]=[C:11]([NH:36]C(=O)C)[CH:10]=1.[CH:40]1([S:43](Cl)(=[O:45])=[O:44])[CH2:42][CH2:41]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([N:15]2[C:19]3[CH:20]=[CH:21][C:22]([C:24]4[N:25]=[N:26][N:27]([CH:29]5[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]5)[CH:28]=4)=[CH:23][C:18]=3[N:17]=[CH:16]2)[CH:12]=[C:11]([NH:36][S:43]([CH:40]2[CH2:42][CH2:41]2)(=[O:45])=[O:44])[CH:10]=1

Participants

Reactant 2

HCID 2760919Cyclopropanesulfonyl chloride

HCID 117777724HCID 117777724, compound

Product 1

HCID 117777526HCID 117777526, compound

Procedure

The compound was prepared from the compound of Example 164 using the procedures of Example 165 and cyclopropane sulfonyl chloride. LC-MS (ESI): Calculated mass: 553.61; Observed mass: 554.2 [M+H]+ (rt: 0.57 min).

Workup

custom554.2 [M+H]+ (rt: 0.57 min)

Sources & evidence

ORD record: ord-94165eb988184224a27a1898e1196049
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447091B2

Reaction notes

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