N-{2-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-1,3-thiazol-5-yl}acetamide → n-{5-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)oxy]-2-thienyl}acetamide

HRID 641513Notes

Reaction equation

HRID 641513 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[CH:13][C:14]([O:16][C:17]4[S:18][C:19]([N+:22]([O-])=O)=[CH:20][CH:21]=4)=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.C1(N2CCC3C=[CH:37][C:38]([O:40]C4SC(NC(=O)C)=CN=4)=CC=3CC2)CCC1>>[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[CH:13][C:14]([O:16][C:17]4[S:18][C:19]([NH:22][C:38](=[O:40])[CH3:37])=[CH:20][CH:21]=4)=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10338403N-{2-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-1,3-thiazol-5-yl}acetamideHCID 103828953-Cyclobutyl-7-[(5-nitro-2-thienyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 10043835n-{5-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)oxy]-2-thienyl}acetamide

Procedure

Example 212 (E212) was prepared from 3-cyclobutyl-7-[(5-nitro-2-thienyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine (E211) using an analogous method to that described for Example 210 (E210); MS (ES+) m/e 357 [M+H]+.

Sources & evidence

ORD record
ord-77b0cbbdf2244e7ba82601645a6f2688
Source dataset
uspto-grants-2010_04
Patent number
US07696193B2

Reaction notes

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