Cyclobutanone → HCID 10317899, compound

HRID 641556Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([NH:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[O:12][C:13]1[CH:30]=[CH:29][C:16]2[CH2:17][CH2:18][N:19]([C:22](OC(C)(C)C)=O)[CH2:20][CH2:21][C:15]=2[CH:14]=1.[C:31]1(=O)[CH2:34]C[CH2:32]1>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[O:12][C:13]1[CH:30]=[CH:29][C:16]2[CH2:17][CH2:18][N:19]([CH:22]3[CH2:34][CH2:31][CH2:32]3)[CH2:20][CH2:21][C:15]=2[CH:14]=1)[C:8]([NH:10][CH3:11])=[O:9]

Participants

Reactant 2

HCID 14496Cyclobutanone

HCID 68504848HCID 68504848, compound

Product 1

HCID 10317899HCID 10317899, compound

Procedure

The title compound was prepared from 3-chloro-N-methyl-4-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)benzamide (E267, Step 4) and cyclobutanone using the method outlined in Example 264 Step 7 (36 mg, 57%) MS (ES+), m/e 385 & 387 [M+H]+.

Sources & evidence

ORD record: ord-473f700742d9496b8c1cb615d3dd9a20
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696193B2

Reaction notes

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