HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → lithium 2-(5-(trifluoromethoxy)-1H-indol-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Oxolane--water (1/1) | HCID 21881883 | — |
| Reactant | ethyl 2-(5-(trifluoromethoxy)-1H-indol-2-yl)acetate | HCID 68637441 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | lithium 2-(5-(trifluoromethoxy)-1H-indol-2-yl)acetate | HCID 68638606 | 102.9% |
Reaction Steps
A solution of ethyl 2-(5-(trifluoromethoxy)-1H-indol-2-yl)acetate (96 mg, 0.33 mmol) in 2:1 THF/water (6 mL) was treated with lithium hydroxide (10 mg, 0.4 mmol), and the reaction was stirred overnight. The THF was stripped, and the aqueous was freeze-dried to yield 90 mg of an off-white solid as product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696205B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-8fe99cb3199b4d6e8c49a6cf0b9e9af6 |
| Source note | uspto-grants-2010_04 |