(S)-O-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine → (S)-N-(2,3-Dihydroxypropoxy)-6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Participants

Reaction Steps

Example 37 was synthesized following a similar procedure described in the synthesis of Example 2 by treatment of compound 2A with (S)-O-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine (See, Bailey et al., J. Med. Chem., 34, 1991, 51-65), followed by acid hydrolysis of the resulting material. 1H NMR (400 MHz, CDCl3) δ 7.46 (m, 2 H) 6.79 (t, J=8.0 Hz, 1 H) 3.89 (m, 3 H) 3.66 (m, 1 H) 3.55 (m, 1 H) 3.31 (s, 3 H) 3.02 (s, 3 H). [M+H] calc'd for C16H18FIN4O6, 509; found, 509.

Provenance & Evidence