HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylenediamine → N-(2-Aminoethyl)-6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | Phenyl 6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate | HCID 59259226 | — |
| Product | N-(2-Aminoethyl)-6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide | HCID 25109090 | — |
Reaction Steps
Example 42 was synthesized following a similar procedure described in the synthesis of Example 5 by reaction of compound 2A and ethane-1,2-diamine. 1H NMR (400 MHz, CDCl3) δ 7.67 (d, J=8.0 Hz, 1 H) 7.62 (d, J=8.0 Hz, 1 H) 7.01 (t, J=8.0 Hz, 1 H) 3.63 (t, J=4.0 Hz, 2 H) 3.27 (s, 3 H) 3.15 (t, J=4.0 Hz, 2 H) 3.11 (s, 3 H). [M+H] calc'd for C15H17FIN5O3, 462; found, 462.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696218B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-0d156c7c4f6c4f86bcf27b5703d38670 |
| Source note | uspto-grants-2010_04 |