1-(2-Hydroxyethyl)piperazine → HCID 25109091, compound

HRID 641612Notes

Reaction equation

HRID 641612 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]([CH3:16])[C:14](=[O:17])[N:13]([CH3:18])[C:12](=[O:19])[C:11]=1[C:20](OC1C=CC=CC=1)=[O:21].[N:29]1([CH2:35][CH2:36][OH:37])[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]([CH3:16])[C:14](=[O:17])[N:13]([CH3:18])[C:12](=[O:19])[C:11]=1[C:20]([N:32]1[CH2:33][CH2:34][N:29]([CH2:35][CH2:36][OH:37])[CH2:30][CH2:31]1)=[O:21]

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 59259226Phenyl 6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Product 1

HCID 25109091HCID 25109091, compound

Procedure

Example 44 was synthesized following a similar procedure described in the synthesis of Example 5 by reaction of compound 2A and 2-(piperazin-1-yl)ethanol. 1H NMR (400 MHz, CDCl3) δ 7.55 (m, 2 H) 6.95 (t, J=8.0 Hz, 1 H) 4.17 (br, 1 H) 3.86 (br, 3 H) 3.54 (br, 5 H) 3.33 (br, 1 H) 3.28 (br, 5 H) 3.10 (br, 2 H) 2.37 (br, 1 H). [M+H] calc'd for C19H23FIN5O4, 532; found, 532.

Workup

  1. customExample 44 was synthesized

Sources & evidence

ORD record
ord-ed68d71dcd214a579c2555f7d25b4b0b
Source dataset
uspto-grants-2010_04
Patent number
US07696218B2

Reaction notes

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