1,1-Dimethylhydrazine → 6-(2-Fluoro-4-iodophenylamino)-N',N',1,3-tetramethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide

Participants

Role	Name	HCID	Charge
Reactant	1,1-Dimethylhydrazine	HCID 5976	—
Reactant	Phenyl 6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate	HCID 59259226	—
Product	6-(2-Fluoro-4-iodophenylamino)-N',N',1,3-tetramethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide	HCID 25109092	—

Reaction Steps

Example 45 was synthesized following a similar procedure described in the synthesis of Example 5 by reaction of compound 2A and 1,1-dimethylhydrazine. 1H NMR (400 MHz, CDCl3) δ 7.66 (d, J=8.0 Hz, 1 H) 7.58 (d, J=8.0 Hz, 1 H) 6.99 (t, J=8.0 Hz, 1 H) 3.33 (s, 3 H) 3.08 (s, 3 H) 2.60 (s, 6 H). [M+H] calc'd for C15H17FIN5O3, 462; found, 462.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07696218B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-65a0b98c93194567a84cf0690970e2a6
Source note	uspto-grants-2010_04