HCID 11517728, compound → HCID 11698104, compound

HRID 641628Notes

Reaction equation

HRID 641628 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[C:21]3[CH:22]=[CH:23][S:24][C:20]=3[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH:13]2[CH2:25][CH3:26])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[Br:27]C1SC2C3C=CC=CC=3C(C)N(S(C3C=CC(O)=CC=3)(=O)=O)C=2C=1>>[Br:27][C:23]1[S:24][C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH:13]([CH2:25][CH3:26])[N:12]([S:9]([C:6]3[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=3)(=[O:11])=[O:10])[C:21]=2[CH:22]=1

Participants

3

Reactant 2

HCID 11517728HCID 11517728, compoundHCID 68579644HCID 68579644, compound

Product 1

HCID 11698104HCID 11698104, compoundYield 20%

Procedure

Starting from 4-[(4-Methoxyphenyl)sulfonyl]-5-ethyl-4,5-dihydrothieno[3,2-c]isoquinoline in place of 4-[(4-Methoxyphenyl)sulfonyl]-5-methyl-4,5-dihydrothieno[3,2-c]isoquinoline (Step 1), the title compound (0.19 g tan solid, 20%, m.p. 183-85° C.) was synthesized in essentially the same manner as described in Example 6, Method B, Steps 1-2, for 4-[(2-Bromo-5-methylthieno[3,2-c]isoquinolin-4(5H)-yl)sulfonyl]phenol.

Sources & evidence

ORD record
ord-b648429ee85f4f27b5f66eec49cb2f70
Source dataset
uspto-grants-2010_04
Patent number
US07696221B2

Reaction notes

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