Pyrido[2,3-d]pyrimidin-7(8H)-one → HCID 59258967, compound

HRID 641653Notes

Reaction equation

HRID 641653 reaction equation
[CH:1]1([N:5]2[C:10]3[N:11]=[C:12](S(C)=O)[N:13]=[C:14]([CH3:15])[C:9]=3[CH:8]=[C:7]([C:19]3[CH:20]=[N:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)[C:6]2=[O:27])[CH2:4][CH2:3][CH2:2]1.[N:28]1C2NC(=O)C=CC=2C=N[CH:29]=1>>[CH:1]1([N:5]2[C:10]3[N:11]=[C:12]([NH:28][CH3:29])[N:13]=[C:14]([CH3:15])[C:9]=3[CH:8]=[C:7]([C:19]3[CH:20]=[N:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)[C:6]2=[O:27])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10012049Pyrido[2,3-d]pyrimidin-7(8H)-oneHCID 59258872HCID 59258872, compound

Product 1

HCID 59258967HCID 59258967, compoundYield 35%

Procedure

Following the procedure described in Example 22, using 8-cyclobutyl-6-(6-methoxypyridin-3-yl)-4-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one in place of 6-(6-methoxypyridin-3-yl)-4-methyl-2-ethylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one, the title compound was obtained in 35% yield.

Sources & evidence

ORD record
ord-63baf9f27acc499997fb0ff9e5374130
Source dataset
uspto-grants-2010_04
Patent number
US07696213B2

Reaction notes

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