Ammonium Chloride → HCID 19696324, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) solution of the product of Step 5 (12 g) in 150 mL of MeOH was added 2 g of NaBH4. After stirring for 30 min at 0° C., 100 mL of saturated aqueous solution of NH4Cl was added and the mixture was extracted with EtOAc (500 mL). The extract was dried over Na2SO4 and filtered. The filtrate was concentrated to give the crude title compound which was used for next step without further purification. 1H NMR (500 MHz, acetone-d6) δ 7.46 (d, 1H), 7.30 (d, 1H), 7.07 (t, 1H), 7.00 (t, 1H), 6.15 (s, 1H), 4.40 (m, 1H), 4.25 (dd, 1H), 3.91 (dd, 1H), 3.20 (m, 1H), 2.46 (m, 1H), 2.10 (m, 1H). 2.00 (m, 1H).

Provenance & Evidence