Methanol → HCID 58399162, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.9 g of the product of Step 9 in 50 mL of CH2Cl2 was added 0.42 mL of oxalyl chloride at 0° C. After stirring for 1 h at 0° C., 4 mL of MeOH was added and the mixture was stirred for another hour and quenched with 30 mL of saturated aqueous solution of NaHCO3. The mixture was extract with 50 mL of CH2Cl2 and the extract was dried over Na2SO4. After filtration, the filtrated was concentrated to give 1.2 of the title product as a solid. 1H NMR (500 MHz, acetone-d6) d 8.11 (m, 2H), 7.92 (m, 1H), 7.45-7.52 (m, 3H), 7.28-7.34 (m, 2H, 4.70 (m, 1H), 7.32 (m, 1H), 4.12 (t, 1H), 3.97 (s, 3H), 3.48-3.55 (m, 1H), 3.08-3.07 (m, 1H), 3.00 (s, 3H), 2.10 (m, 1H), 1.76 (m, 1H).

Provenance & Evidence