Acetic Acid → HCID 16063374, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 85 mg of the product from Step 2 in 2 mL of THF and 3 mL of MeOH was added 0.5 mL of 2N NaOH. The mixture was heated at 50° C. for 8 h and 1 mL of AcOH was then added, and concentrated. The residue was suspended in 5 mL of water and the solid was collected by filtration, and then purified by Combiflash eluted with a gradient up to 70% EtOAc/hexane containing 5% of AcOH to give 9 mg of the title compound (eluted first). 1H NMR (500 MHz, acetone-d6) d 8.12 (m, 2H), 7.87 (d, 1H), 7.87 (m, 1H), 7.48 (t, 1H), 7.42 (m, 1H), 7.28 (m, 2H), 6.28 (d, 1H), 4.65 (m, 1H), 4.27 (m, 1H), 4.04 (t, 1H), 3.49 (m, 1H), 3.10 (m, 1H), 3.02 (s, 3H), 2.10 (m, 1H), 1.78 (m, 1H).

Provenance & Evidence